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To further confirm the identification of 4-OXO-DHA as a metabolite in plasma of rats fed DHA, co-chromatography of plasma samples spiked with the synthetic standard 4-OXO-DHA was conducted

Mazariegos G, Shneider B, Burton B, Fox IJ, Hadzic N, Kishnani P, et al

Disease Prevention Immune dysfunction Several enzymatic reactions in the tryptophan-kynurenine pathway are dependent on vitamin B 6 coenzyme, pyridoxal 5'-phosphate (PLP) (see Figure 2 ) (see Tryptophan metabolism)